Methylene Blue USP and Methylthioninium Chloride BP Ph Eur Grade Manufacturers Exporters |
| Aadhunik Industries is a manufacturing group company. Aadhunik Industries is pioneer manufacturers of Methylene Blue USP and Methylthioninium Chloride, Specialty Chemicals, Pharmaceutical Excipients, Food Fragrance & Flavor chemicals in India. It has toll manufacturers and representatives in UAE, Europe, Canada & USA and agents & customers in all countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Netherlands, Italy, Spain, Germany, Portugal, France, Malaysia, Indonesia, Thailand, Korea, Japan, Russia etc. |
| Aadhunik Industries and/or associated units are FDA-GMP certified, Halal and/or Kosher certified, REACH registered, ISO-9001, ISO-22000 HACCP certified. We offer crystals granules in precise micron or mesh size as per buyers needs. We offer very high purity standards as per specifications required. |
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SDS MSDS of Methylene Blue and Methylthioninium Chloride Manufacturers
Specifications of Methylene Blue USP Grade Show/Hide Details
Methylene Blue USP
C16H18ClN3S·3H2O 373.90
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate.
C.I. Basic Blue 9 trihydrate [7220-79-3]
Anhydrous 319.86 [CAS 61-73-4]
Methylene Blue contains not less than 98.0 percent and not more than 103.0 percent of C16H18ClN3S, calculated on the dried basis.
Identification: Infrared Absorption 197K .
Loss on drying: Dry it at 75 and at a pressure not exceeding 5 mm of mercury for 4 hours: it loses between 8.0% and 18.0% of its weight.
Residue on ignition: not more than 1.2%.
Arsenic: Prepare the Test Preparation by mixing 0.375 g with 10 mL of water in the arsine generator flask. Add 15 mL of nitric acid and 5 mL of perchloric acid, mix, and heat cautiously to the production of strong fumes of perchloric acid. Cool, wash down the sides of the flask with water, and again heat to strong fumes. Again cool, wash down the sides of the flask, and heat to fumes. Cool, dilute with water to 52 mL, and add 3 mL of hydrochloric acid: the resulting solution meets the requirements of the test, the addition of 20 mL of 7 N sulfuric acid specified for Procedure being omitted. The limit is 8 ppm.
Copper or zinc: Ignite 1.0 g in a porcelain crucible, using as low a temperature as practicable, until all of the carbon is oxidized. Cool the residue, add 15 mL of 2 N nitric acid, and boil for 5 minutes. Filter the cooled solution, and wash any residue with 10 mL of water. To the combined filtrate and washing add an excess of 6 N ammonium hydroxide, and filter the solution into a 50 mL volumetric flask. Wash the precipitate with small portions of water, adding the washings to the filtrate, dilute the solution with water to volume, and mix. To 25 mL of the solution add 10 mL of hydrogen sulfide TS: no turbidity is produced within 5 minutes (absence of zinc). Any dark color produced does not exceed that of a control prepared by boiling a quantity of cupric sulfate, equivalent to 200 @g of copper, with 15 mL of 2 N nitric acid for 5 minutes and by treating this solution as directed above, beginning with “Filter the cooled solution” (0.02% of copper).
Specifications of Methylthioninium Chloride BP Ph Eur Grade Show/Hide Details
Methylthioninium Chloride BP Ph Eur Grade:
C16H18ClN3S,xH2O --- 319.9 (anhydrous substance)
Action and use: Reducing agent; antidote to methaemoglobinaemia.
DEFINITION
3,7-Bis(dimethylamino)phenothiazin-5-ylium chloride (methylene blue).
Content: 93.0 per cent to 102.0 per cent (dried substance).
It contains a variable quantity of water.
CHARACTERS
Appearance: Dark blue or dark green crystalline powder with a metallic sheen, hygroscopic.
Solubility: Slightly soluble in water and in ethanol (96 per cent).
IDENTIFICATION
A. Ultraviolet and visible absorption spectrophotometry.
B. Thin-layer chromatography.
C. Ignite 50 mg with 0.5 g of anhydrous sodium carbonate. Cool and dissolve the residue in 10 mL of dilute nitric acid. Filter. The filtrate, without further addition of dilute nitric acid gives reaction (a) of chlorides.
TESTS
Related substances: To pass the test by Liquid chromatography.
Limits:
- impurity A: maximum 5.0 per cent;
- unspecified impurities: for each impurity, maximum 0.10 per cent;
- total of impurities other than A: maximum 0.5 per cent;
- reporting threshold: 0.05 per cent.
Metals: To pass the test.
Loss on drying: 8.0 per cent to 24.0 per cent, determined on 1.000 g by drying in an oven at 105C for 5 h.
Sulfated ash: Maximum 0.25 per cent, determined on 1.0 g.
CAS Number 7220-79-3 and 61-73-4, Methylene Blue USP and Methyl thioninium Chloride manufacturers suppliers exporters at:
manufacturer supplier exporter
Aadhunik Industries
Ankleshwar Gujarat & Mumbai, India
TEL: (OFFICE) 91-22-23774610, 23723564.
e-mail: info@aadhunikindustries.com
Copyright and Usual Disclaimer is Applicable. 7-12-2022
Acetic Acid Glacial ------- Ammonium Bicarbonate ------- Aluminum Chloride ------- Aluminium Potassium Sulphate ------- Ammonium Carbonate ------- Ammonium Carbamate ------- Ammonium Chloride ------- Ammonium Persulfate------- Barium Chloride ------- Benzyl Alcohol ------- Benzoic Acid ------- Boric Acid ------- Borax ------- Calcium Chloride ------- Calcium Oxide ------- Calcium Hydroxide ------- Calcium Lactobionate ------- Calcium D Saccharate ------- Calcium Sulfate ------- Carbamide Peroxide ------- Chromic Chloride -------Copper Cupric Chloride ------- Copper Sulphate ------- Precipitated Coated & Directly Compressible Calcium Carbonate ------- Fumaric Acid ------- Ferric Chloride ------- Formaldehyde Solution ------- Lithium Carbonate ------- Magnesium Chloride ------- Magnesium Sulphate ------- Maleic Acid ------- Malic Acid ------- Manganese Chloride ------- Manganese Sulphate ------- Octyl Dodecanol ------- Oleic Acid ------- Phenyl Ethanol ------- Potassium Bromide ------- Potassium Chloride ------- Potassium Hydroxide Pellets ------- Potassium Monopersulfate ------- Potassium Phosphate Monobasic Dibasic Tribasic ------- Propylene Carbonate ------- Selenious Acid ------- Sodium Acetate ------- Sodium Diacetate ------- Sodium Hydroxide Pellets------- Sodium Thiosulfate ------- Sodium Formaldehyde Bisulfite ------- Sodium Perborate ------- Vanadyl Sulfate ------- Zinc Chloride